| Date | Opponent | Location | Time | Media | Results | POTG |
|---|---|---|---|---|---|---|
| 08/17/12 | Chinese Olympic Team | Kunshan, China | 8:00 AM | W 77-64 | Austin Rivers | |
| 08/18/12 | Chinese Olympic Team | Shanghai, China | 8:00 AM | ESPNU/ ESPN3.com | W 78-66 | Ryan Kelly |
| 08/22/12 | Chinese Olympic Team | Beijing, China | 8:00 AM | ESPNU/ ESPN3.com | W 93-78 | Ryan Kelly |
| 08/25/12 | UAE National Team | Dubai, UAE | 1:30 PM | ESPNU/ ESPN3.com | W 86-66 | Andre Dawkins |
| 10/14/12 | Countdown to Craziness | Durham, NC | 8:00 PM | ESPN3 | W 56-53 | Seth Curry |
| 10/29/12 | Bellarmine (Exhibition) | Durham, NC | 7:00 PM | W 87-62 | Seth Curry | |
| 11/02/12 | Shaw (Exhibition) | Durham, NC | 7:00 PM | W 80-66 | Ryan Kelly | |
| 11/11/12 | Belmont (Maui Invitational) | Durham, NC | 9:00 PM | ESPNU | W 77-76 | Mason Plumlee |
| 11/12/12 | Presbyterian (Maui Invitational) | Durham, NC | 4:30 PM | ESPNU | W 96-55 | Austin Rivers |
| 11/15/12 | Michigan State (Champions Classic) | New York, NY MSG | 7:00 PM | ESPN | W 74-69 | Andre Dawkins |
| 11/18/12 | Davidson | Durham, NC | 6:00 PM | ESPNU | W 82-69 | Mason Plumlee |
| 11/21/12 | Tennessee - Quarterfinals (Maui Invitational) | Lahaina, HI | 5:30 PM | espn2 | W 77-67 | Ryan Kelly |
| 11/22/12 | Michigan - Semifinals (Maui Invitational) | Lahaina, HI | 7:00 PM | ESPN | W 82-75 | Austin Rivers |
| 11/23/12 | Kansas - Championship (Maui Invitational) | Lahaina, HI | 10:00 PM | ESPN | W 68-61 | Tyler Thornton |
| 11/29/12 | Ohio State (Big Ten/ACC Challenge) | Columbus, OH | 9:30 PM | ESPN | L 63-85 | Austin Rivers |
| 12/07/12 | Colorado State | Durham, NC | 7:00 PM | ESPNU | W 87-64 | Mason Plumlee |
| 12/10/12 | Washington | New York, NY MSG | 12:00 PM | CBS | W 86-80 | Ryan Kelly |
| 12/19/12 | UNC Greensboro | Durham, NC | 7:00 PM | ESPN3 | W 90-63 | Mason Plumlee |
| 12/30/12 | Western Michigan | Durham, NC | 7:00 PM | espn2 | W 110-70 | Quinn Cook |
| 01/01/12 | Pennsylvania | Durham, NC | 5:00 PM | ESPNU | W 85-55 | Ryan Kelly |
| 01/04/12 | Temple | Philadelphia, PA Wells Fargo Center | 7:00 PM | espn2 | L 73-78 | Mason Plumlee |
| 01/07/12 | Georgia Tech * | Atlanta, GA Philips Arena | 12:00 PM | ESPNU | W 81-74 | Ryan Kelly |
| 01/12/12 | Virginia * | Durham, NC | 9:00 PM | ESPN/ espn2 | W 61-58 | Mason Plumlee |
| 01/15/12 | Clemson * | Clemson, SC | 6:00 PM | ESPNU | W 73-66 | Andre Dawkins |
| 01/19/12 | Wake Forest * | Durham, NC | 7:00 PM | ESPN/ espn2 | W 91-73 | Andre Dawkins |
| 01/21/12 | Florida State * | Durham, NC | 4:00 PM | ESPN | L 73-76 | Austin Rivers |
| 01/25/12 | Maryland * | College Park, MD | 9:00 PM | ESPN | W 74-61 | Mason Plumlee |
| 01/28/12 | St. John's | Durham, NC | 12:00 PM | ESPN/ espn2 | W 83-76 | Mason Plumlee |
| 02/02/12 | Virginia Tech * | Blacksburg, VA | 7:00 PM | ESPN/ espn2 | W 75-60 | Austin Rivers |
| 02/05/12 | Miami * | Durham, NC | 3:00 PM | ESPNU | L 74-78 | Seth Curry |
| 02/08/12 | North Carolina * | Chapel Hill, NC | 9:00 PM | ESPN/ ACC Network | W 85-84 | Austin Rivers |
| 02/11/12 | Maryland * | Durham, NC | 4:00 PM | ESPN | W 73-55 | Miles Plumlee |
| 02/16/12 | NC State * | Durham, NC | 9:00 PM | ACC Network | W 78-73 | Seth Curry |
| 02/19/12 | Boston College * | Chestnut Hill, MA | 6:00 PM | ESPNU | W 75-50 | Austin Rivers |
| 02/23/12 | Florida State * | Tallahassee, FL | 7:00 PM | ESPN/ espn2 | W 74-66 | Austin Rivers |
| 02/25/12 | Virginia Tech * | Durham, NC | 12:00 PM | ACC Network | W 70-65 | Austin Rivers |
| 02/28/12 | Wake Forest * | Winston-Salem, NC | 9:00 PM | ESPNU | W 79-71 | Ryan Kelly |
| 03/03/12 | North Carolina * | Durham, NC | 7:00 PM | ESPN | L 88-70 | Miles Plumlee |
| 03/08/12 | Virginia Tech (ACC Tournament) | Atlanta, GA Philips Arena | 7:00 PM | ESPN/ ACC Network | W 60-56 | Austin Rivers |
| 03/09/12 | Florida State (ACC Tournament) | Atlanta, GA Philips Arena | 3:35 PM | ESPN/ ACC Network | L 59-62 | Miles Plumlee |
| 03/16/12 | Lehigh (NCAA Tournament) | Greensboro | 7:15 PM | CBS | L 7-75 | Mason Plumlee |