| Date | Opponent | Location | Time | Media | Results | POTG |
| Aug 17 | Chinese Olympic Team | Kunshan, China | 8:00 am |
|
W 77-64 | Austin Rivers |
| Aug 18 | Chinese Olympic Team | Shanghai, China | 8:00 am |
ESPNU/ ESPN3.com |
W 78-66 | Ryan Kelly |
| Aug 22 | Chinese Olympic Team | Beijing, China | 8:00 am |
ESPNU/ ESPN3.com |
W 93-78 | Ryan Kelly |
| Aug 25 | UAE National Team | Dubai, UAE | 1:30 pm |
ESPNU/ ESPN3.com |
W 86-66 | Andre Dawkins |
| Oct 14 | Countdown to Craziness | Durham, NC | 8:00 pm | ESPN3 |
W 56-53 |
Seth Curry |
| Oct 29 |
Bellarmine (Exhibition) |
Durham, NC | 7:00 pm | W 87-62 | Seth Curry | |
| Nov 02 |
Shaw (Exhibition) |
Durham, NC | 7:00 pm | W 80-66 | Ryan Kelly | |
| Nov 11 |
Belmont (Maui Invitational) |
Durham, NC | 9:00 pm | ESPNU | W 77-76 | Mason Plumlee |
| Nov 12 |
Presbyterian (Maui Invitational) |
Durham, NC | 4:30 pm | ESPNU | W 96-55 | Austin Rivers |
| Nov 15 |
Michigan State (Champions Classic) |
New York, NY MSG |
7:00 pm | ESPN | W 74-69 | Andre Dawkins |
| Nov 18 | Davidson | Durham, NC |
6:00 pm |
ESPNU | W 82-69 | Mason Plumlee |
| Nov 21 |
Tennessee - Quarterfinals (Maui Invitational) |
Lahaina, HI | 5:30 pm | espn2 | W 77-67 | Ryan Kelly |
| Nov 22 |
Michigan - Semifinals (Maui Invitational) |
Lahaina, HI | 7:00 pm | ESPN | W 82-75 | Austin Rivers |
| Nov 23 |
Kansas - Championship (Maui Invitational) |
Lahaina, HI | 10:00 pm | ESPN | W 68-61 | Tyler Thornton |
| Nov 29 |
Ohio State (Big Ten/ACC Challenge) |
Columbus, OH | 9:30 pm | ESPN | L 63-85 | Austin Rivers |
| Dec 07 | Colorado State | Durham, NC |
7:00 pm |
ESPNU | W 87-64 | Mason Plumlee |
| Dec 10 | Washington |
New York, NY MSG |
12:00 pm | CBS | W 86-80 | Ryan Kelly |
| Dec 19 | UNC Greensboro | Durham, NC |
7:00 pm |
ESPN3 | W 90-63 | Mason Plumlee |
| Dec 30 | Western Michigan | Durham, NC |
7:00 pm |
espn2 | W 110-70 | Quinn Cook |
| Jan 01 | Pennsylvania | Durham, NC |
5:00 pm |
ESPNU | W 85-55 | Ryan Kelly |
| Jan 04 | Temple |
Philadelphia, PA Wells Fargo Center |
7:00 pm | espn2 | L 73-78 | Mason Plumlee |
| Jan 07 | Georgia Tech * |
Atlanta, GA Philips Arena |
12:00 pm | ESPNU | W 81-74 | Ryan Kelly |
| Jan 12 | Virginia * | Durham, NC | 9:00 pm |
ESPN/ espn2 |
W 61-58 | Mason Plumlee |
| Jan 15 | Clemson * | Clemson, SC |
6:00 pm |
ESPNU | W 73-66 | Andre Dawkins |
| Jan 19 | Wake Forest * | Durham, NC | 7:00 pm |
ESPN/ espn2 |
W 91-73 | Andre Dawkins |
| Jan 21 | Florida State * | Durham, NC |
4:00 pm |
ESPN | L 73-76 | Austin Rivers |
| Jan 25 | Maryland * | College Park, MD |
9:00 pm |
ESPN | W 74-61 | Mason Plumlee |
| Jan 28 | St. John's | Durham, NC | 12:00 pm |
ESPN/ espn2 |
W 83-76 | Mason Plumlee |
| Feb 02 | Virginia Tech * | Blacksburg, VA | 7:00 pm |
ESPN/ espn2 |
W 75-60 | Austin Rivers |
| Feb 05 | Miami * | Durham, NC |
3:00 pm |
ESPNU | L 74-78 | Seth Curry |
| Feb 08 | North Carolina * | Chapel Hill, NC | 9:00 pm |
ESPN/ ACC Network |
W 85-84 | Austin Rivers |
| Feb 11 | Maryland * | Durham, NC |
4:00 pm |
ESPN | W 73-55 | Miles Plumlee |
| Feb 16 | NC State * | Durham, NC |
9:00 pm |
ACC Network | W 78-73 | Seth Curry |
| Feb 19 | Boston College * | Chestnut Hill, MA |
6:00 pm |
ESPNU | W 75-50 | Austin Rivers |
| Feb 23 | Florida State * | Tallahassee, FL | 7:00 pm |
ESPN/ espn2 |
||
| Feb 25 | Virginia Tech * | Durham, NC |
12:00 pm |
ACC Network | ||
| Feb 28 | Wake Forest * | Winston-Salem, NC |
9:00 pm |
ESPNU | ||
| Mar 03 | North Carolina * | Durham, NC |
7:00 pm |
ESPN | ||
| Mar 08 |
TBA (ACC Tournament) |
Atlanta, GA Philips Arena |
TBA |
ESPN/ ACC Network |
||
| Mar 09 |
TBA (ACC Tournament) |
Atlanta, GA Philips Arena |
TBA |
ESPN/ ACC Network |
||
| Mar 10 |
TBA (ACC Tournament) |
Atlanta, GA Philips Arena |
TBA |
ESPN/ ACC Network |
||
| Mar 11 |
TBA (ACC Tournament) |
Atlanta, GA Philips Arena |
TBA |
ESPN/ ACC Network |
